ACVRL1 Protein (C-human IgG1-Fc & His, Mouse)
Product Specifications
Abbreviation
ACVRL1
Synonyms
Acvrl1, Acvrlk1, Alk-1, Alk1
Host
HEK 293
Tag
C-human IgG1-Fc & His
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
≥ 90 % as determined by SDS-PAGE
Bioactivity
Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. The ED50 for this effect is typically 3-15ng/mL in the presence of 2 ng/mL of recombinant human BMP9.
Function
Met1-Pro119
Molecular Weight
The secreted recombinant mouse ALK1/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer comprises 345 amino acids with a predicted molecular mass of 39 kDa. As a result of glycosylation, it migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing conditions.
Species
Mouse
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