HAVCR2 Protein (C-His, Human)

Product Specifications

Abbreviation

HAVCR2

Synonyms

CD366, FLJ14428, HAVcr-2, KIM-3, SPTCL, Tim-3, TIM3, TIMD-3, TIMD3

Host

HEK 293

Tag

C-His

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Purity

≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

Bioactivity

1.Captured Anti-TIM-3 Mab (Human IgG4) on proA Chip can bind TIM-3 (Cat.No.10390-H08H) with an affinity constant of 2.351 nM as determined in a SPR assay (Biacore T200) (Routinely tested) . 2.Immobilized Recombinant Human TIM-3 / HAVCR2 Protein (His Tag) (Cat: 10390-H08H) at 0.2 μg/mL (100 μL/well) can bind Anti-TIM3 (Research Grade Clone ABTIM3-hum11), the EC50 is 5-20 ng/mL (QC tested) .

Function

Met1-Arg200

Molecular Weight

The recombinant human HAVCR2 consists of 190 amino acids and predicts a molecular mass of 21.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of human HAVCR2 is approximately 42.8 kDa due to glycosylation.