LDLR Protein (C-His, Human)

Product Specifications

Abbreviation

LDLR

Synonyms

FH, FHC, FHCL1, LDLCQ2

Host

HEK 293

Tag

C-His

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

≥ 85 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

Bioactivity

Immobilized Human LDLR/LDL Receptor His (Cat:10231-H08H) at 2 μg/mL (100 μL/well) can bind Mouse PCSK9 mFc (Cat:50251-M05H), the EC50 of Mouse PCSK9 mFc (Cat:50251-M05H) is 100-800 ng/mL.

Function

Met1-Arg788

Molecular Weight

The secreted recombinant human LDLR comprises 777 amino acids with a predicted molecular mass of 86 kDa. As a result of different glycosylation, it migarates with the apparent molecular mass of 110-140 kDa in SDS-PAGE under reducing conditions corresponding to the mature and immature form.