ERBB2 Protein (C-His, Human)
Product Specifications
Abbreviation
ERBB2
Synonyms
C-ERB-2, c-ERB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, MLN19, NEU, NGL, p185 (erbB2), TKR1, VSCN2
Host
HEK 293
Tag
C-His
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 85 % as determined by SDS-PAGE
Bioactivity
1.Immobilized Recombinant Human HER2 / ErbB2 Protein (ECD, domain IV) (His Tag) (Cat: 10004-H08H4) at 1 μg/mL (100 μL/well) can bind Anti-HER2 (Research Grade Trastuzu*mab Biosimilar), the EC50 is 2-8 ng/mL (QC tested) . 2.Immobilized Recombinant Human HER2 / ErbB2 Protein (ECD, domain IV) (His Tag) (Cat: 10004-H08H4) at 2 μg/mL (100 μL/well) can bind Trastuzumab the EC50 is 0.7 ng/mL, This protein has been shown to weakly bind to Pertuzumab in our functional ELISA studies (Routinely tested) .
Function
Pro489-Cys630
Molecular Weight
The recombinant human ERBB2 consists of 153 amino acids and predicts a molecular mass of 17.1 kDa. As a result of glycosylation, human ErbB2 migrates as an approximately 27 kDa protein in SDS-PAGE under reducing conditions.
Species
Human
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