IL-23 (IL23A&IL12B Protein (C-His, Human)
Product Specifications
Abbreviation
IL-23 (IL23A&IL12B
Synonyms
CLMF p40, IL-12 subunit p40, IL-23, IL-23A, IL-23p19, IL23P19, NKSF2, P19, SGRF
Host
HEK 293
Tag
C-His
Applications
Cell culture, ELISA
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
1. Measured by its ability to bind biotinylated recombinant human IL12RB1 in a functional ELISA. 2. Immobilized human IL23A-His+IL12B-His at 10 μg/ml (100 μl/well) can bind human IL23R-Fc. The EC50 of human IL23R-Fc is 0.28-0.66 μg/ml. 3. Immobilized human IL23A-His+IL12B-His at 10 μg/ml (100 μl/well) can bind Cynomolgus IL23R-Fc. The EC50 of Cynomolgus IL23R-Fc is 0.14-0.35 μg/ml. 4. Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
Function
Met 1-Pro189&Met 1-Ser 28
Molecular Weight
20.1&36.2 kDa
Species
Human
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