ML 297

ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy[1][2].

Product Specifications

CAS Number

[1443246-62-5]

Product Name Alternative

VU 0456810; CID 56642816

UNSPSC

12352005

Hazard Statement

H410

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml-297.html

Purity

99.14

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

FC1=C(F)C=CC(NC(NC2=CC(C)=NN2C3=CC=CC=C3)=O)=C1

Molecular Formula

C17H14F2N4O

Molecular Weight

328.32

Precautions

H410

References & Citations

[1]Wen W, et al. Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23 (16) :4562-6.|[2]Kaufmann K, et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4 (9) :1278-86.