R-348 (choline)

R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection[1].

Product Specifications

CAS Number

[1620142-65-5]

Product Name Alternative

R-932348 (choline)

UNSPSC

12352005

Target

Interleukin Related; JAK; Syk

Type

Reference compound

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-348-choline.html

Smiles

C[N+](CCO)(C)C.CCC([N-]S(=O)(C1=CC(NC2=NC=C(C(NC3=CC=C(C=C3)OCC#C)=N2)F)=CC=C1C)=O)=O

Molecular Formula

C28H35FN6O5S

Molecular Weight

586.68

References & Citations

[1]Deuse T, et al. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27;85 (6) :885-92.