P-Xylene bis (pyridinium bromide)
P-Xylene bis (pyridinium bromide) (compound 21), a cationic charged quencher, is a week bisquaternary AChE and BChE inhibitor with IC50s of 1540 μM and 529 μM, respectively[1][2].
Product Specifications
CAS Number
14208-10-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p-xylene-bis-pyridinium-bromide.html
Purity
99.60
Solubility
DMSO : 6.67 mg/mL (ultrasonic)
Smiles
C1=CC=[N+](C=C1)CC2=CC=C(C=C2)C[N+]3=CC=CC=C3.[Br-].[Br-]
Molecular Formula
C18H18Br2N2
Molecular Weight
422.16
Precautions
H315, H319, H335
References & Citations
[1]Kamil Musilek, et al. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications. Bioorg Med Chem Lett. 2010 Mar 1;20 (5) :1763-6. |[2]M Smolarsky, et al. A simple fluorescent method to determine complement-mediated liposome immune lysis. J Immunol Methods. 1977;15 (3) :255-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Available Sizes
Frequently Asked Questions
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