P-Xylene bis (pyridinium bromide)

P-Xylene bis (pyridinium bromide) (compound 21), a cationic charged quencher, is a week bisquaternary AChE and BChE inhibitor with IC50s of 1540 μM and 529 μM, respectively[1][2].

Product Specifications

CAS Number

[14208-10-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/p-xylene-bis-pyridinium-bromide.html

Purity

99.60

Solubility

DMSO : 6.67 mg/mL (ultrasonic)

Smiles

C1=CC=[N+](C=C1)CC2=CC=C(C=C2)C[N+]3=CC=CC=C3.[Br-].[Br-]

Molecular Formula

C18H18Br2N2

Molecular Weight

422.16

Precautions

H315, H319, H335

References & Citations

[1]Kamil Musilek, et al. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications. Bioorg Med Chem Lett. 2010 Mar 1;20 (5) :1763-6. |[2]M Smolarsky, et al. A simple fluorescent method to determine complement-mediated liposome immune lysis. J Immunol Methods. 1977;15 (3) :255-65.