ALK-1/ACVRL1 Protein (C-hFc, Human)

Product Specifications

Abbreviation

ALK-1/ACVRL1

Synonyms

ACVRL1, ACVRLK1, ALK-1, ALK1, Activin Receptor-Like Kinase 1, HHT, HHT2, ORW2, SKR3, Serine/Threonine-Protein Kinase Receptor R3, TGF-B Superfamily Receptor Type I, TSR-I

UniProt

P37023

Host

HEK 293

Tag

C-hFc

Applications

Cell culture

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 97 % as determined by reducing SDS-PAGE.

Bioactivity

1. Measured by its ability to bind Human ENG-Fc, latent TGFB1-His, mouse ENG-His in functional Elisa. 2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.