ACVR2B/ActivinR-IIB Protein (C-hFc, Human)

Product Specifications

Abbreviation

ACVR2B/ActivinR-IIB

Synonyms

ACTR-IIB, ACVR2B, Activin Receptor Type IIB, Activin Receptor Type-2B, BMP Type II Receptor, BMP Type-2 Receptor, BMPR-5, Bone Morphogenetic Protein Receptor Type II, Bone Morphogenetic Protein Receptor Type-2

UniProt

Q13705

Host

HEK 293

Tag

C-hFc

Applications

Cell culture, ELISA

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 97 % as determined by reducing SDS-PAGE.

Bioactivity

1. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.02-0.1 μg/mL in the presence of 10 ng/mL recombinant Activin A. 2. Immobilized Inhibin Human, Mouse, Rat, Cynomolgus, Rhesus Inhibin beta A/Activin A at 2 μg/ml (100 μl/well) can bind Human ACVR2B hFc, the EC50 of Human ACVR2B hFc is 12-60 ng/mL.