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PDHK-IN-7

PDHK-IN-7 (compound 32) is an inhibitor of pyruvate dehydrogenase kinase with an IC50 value of 17 nM.PDHK-IN-7 activates PDH in rat livers and has a glucose-lowering effect in Zucker fatty rats[1].

Product Specifications

CAS Number

1220965-73-0

UNSPSC

12352005

Target

PDHK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pdhk-in-7.html

Smiles

CC1=CC2=C(C3=CC=CC=C3C2(O)C(F)(F)F)C(C4=CN(CCO)N=C4)=C1

Molecular Formula

C20H17F3N2O2

Molecular Weight

374.36

References & Citations

[1]Masafumi Inoue, et al. Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg Med Chem Lett. 2024 Sep 1:109:129839.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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