PDHK-IN-7
PDHK-IN-7 (compound 32) is an inhibitor of pyruvate dehydrogenase kinase with an IC50 value of 17 nM.PDHK-IN-7 activates PDH in rat livers and has a glucose-lowering effect in Zucker fatty rats[1].
Product Specifications
CAS Number
1220965-73-0
UNSPSC
12352005
Target
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pdhk-in-7.html
Smiles
CC1=CC2=C(C3=CC=CC=C3C2(O)C(F)(F)F)C(C4=CN(CCO)N=C4)=C1
Molecular Formula
C20H17F3N2O2
Molecular Weight
374.36
References & Citations
[1]Masafumi Inoue, et al. Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg Med Chem Lett. 2024 Sep 1:109:129839.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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