JNJ-37822681 (dihydrochloride)

JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1][2].

Product Specifications

CAS Number

[2108806-02-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jnj-37822681-dihydrochloride.html

Concentration

10mM

Purity

98.69

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

FC(C1=NN=C(NC2CCN(CC3=CC=C(F)C(F)=C3)CC2)C=C1)(F)F.Cl.Cl

Molecular Formula

C17H19Cl2F5N4

Molecular Weight

445.26

Precautions

H315, H319, H320

References & Citations

[1]Langlois X, et, al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342 (1) :91-105.|[2]de Waal EJ, et, al. Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics. J Appl Toxicol. 2014 Sep;34 (9) :974-92.