AICAR (Standard)

AICAR (Standard) is the analytical standard of AICAR. This product is intended for research and analytical applications. AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor[1][2].

Product Specifications

CAS Number

[2627-69-2]

Product Name Alternative

Acadesine (Standard) ; AICA Riboside (Standard)

UNSPSC

12352005

Target

AMPK; Autophagy; Endogenous Metabolite; Mitophagy; Reference Standards; YAP

Type

Reference Standards

Related Pathways

Autophagy; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aicar-standard.html

Purity

99.91

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N)=C(N=C2)C(N)=O)O1

Molecular Formula

C9H14N4O5

Molecular Weight

258.23

References & Citations

[1]Nakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the IR expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328 (2) :449-54|[2]Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299 (6) :R1546-54.|[3]Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54 (4) :928-34.|[4]Giri S, et al. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci. 2004 Jan 14;24 (2) :479-87.|[5]Ajaybabu V Pobbati, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10 (8) :3622-3635.