RO 4938581
RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively) ; RO 4938581 is used in the research of cognitive dysfunction.
Product Specifications
CAS Number
883093-10-5
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/RO_4938581.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=C2N(C3=CC=C(Br)C=C3C4=NC=NN4C2)C=N1)F
Molecular Formula
C13H8BrF2N5
Molecular Weight
352.14
Precautions
H315, H319, H320
References & Citations
[1]Knust H, et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett. 2009 Oct 15;19 (20) :5940-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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