JNJ-74856665
JNJ-74856665 (DHODH-IN-16) is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1].
Product Specifications
CAS Number
[2511248-11-4]
Product Name Alternative
DHODH-IN-16
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhodh-in-16.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C(C(C)C)=CN1C3=C(C)C=CC=C3)C=C(N4N=C(CO)N(CC)C4=O)C(F)=C2
Molecular Formula
C24H25FN4O3
Molecular Weight
436.48
References & Citations
[1]Scott Kuduk, et al. Dihydroorotate dehydrogenase inhibitors. WO2020212897A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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