L-645164
L-645164 is a potent inhibitor of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase. L-645164 produces substantial decreases in circulating serum cholesterol concentrations in dogs. L-645164 is promising for research of central nervous system disorders[1].
Product Specifications
CAS Number
85493-98-7
UNSPSC
12352005
Target
HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1C[C@@H](C[C@H](O1)/C=C/C2=C(C=C(C=C2C3=CC=C(C(C)=C3)F)C)C)O
Molecular Formula
C22H23FO3
Molecular Weight
354.41
References & Citations
[1]Gerson RJ, et al. The toxicity of a fluorinated-biphenyl HMG-CoA reductase inhibitor in beagle dogs. Fundam Appl Toxicol. 1991 Feb;16 (2) :320-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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