Mal-amido-PEG5-C2-NHS ester
Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules[1][2]
Product Specifications
CAS Number
[1315355-92-0]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-amido-peg5-c2-nhs-ester.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O
Molecular Formula
C24H35N3O12
Molecular Weight
557.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Hansen AM, et al. Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. Eur J Med Chem. 2019 Apr 15;168:134-145.|[2]Zhang ge, et al. Preparation and application of FAPalpha activated polypeptide magnetic nanosphere compound used for diagnosis of tumors. CN105524141A
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
Curated Selection
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