Elubrixin (tosylate)
Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM) . Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation[1][2][3].
Product Specifications
CAS Number
960495-43-6
Product Name Alternative
SB-656933 (tosylate)
UNSPSC
12352005
Hazard Statement
H361, H373
Target
CXCR; Interleukin Related
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/elubrixin-tosylate.html
Purity
98.14
Solubility
DMSO : 125 mg/mL (ultrasonic; warming)
Smiles
O=C(NC1=CC=C(Cl)C(S(=O)(N2CCNCC2)=O)=C1O)NC3=CC=CC(F)=C3Cl.OS(=O)(C4=CC=C(C)C=C4)=O
Molecular Formula
C24H25Cl2FN4O7S2
Molecular Weight
635.51
Precautions
H361, H373
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CXCR2; IL-8
Available Sizes
Frequently Asked Questions
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