Anti-GluN2B/NR2B Glutamate Receptor (N59/36) Recombinant Chicken Chimeric mAb

GluN2B/NR2B glutamate receptor, also known as Glutamate/N-methyl D-aspartate/NMDA receptor subtype 2B, is a member of the NMDA receptor family. NMDA receptors are expressed throughout the CNS in postsynaptic cell membranes. GluN2B is a major NMDAR subtype found in cortical and hippocampal regions of the adult brain. NMDA receptors are involved with memory and learning. Mutations in the gene encoding GluN2B are associated with autism, LennoxGastaut and West Syndromes.

Our chicken Anti-GluN2B/NR2B glutamate receptor recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N59/36. It detects human, mouse, and rat GluN2B/NR2B glutamate receptor and is purified by affinity chromatography. It works in WB, IHC, ICC, IP, ELISA.

Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N59/36 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N59/36 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Each new lot of antibody is quality control tested by Western blot on rat brain membrane fraction and confirmed to stain the expected molecular weight band.