Anti-Teneurin-3 (N497/10) Recombinant Chicken Chimeric mAb (BSA and Azide free)

Teneurin-3 is a large type II transmembrane protein belonging to the teneurin family, which plays essential roles in neuronal connectivity, cell adhesion, and developmental patterning. Structurally, Teneurin-3 contains a large extracellular domain with EGF-like repeats, NHL and YD-repeat motifs, and a unique C-terminal peptide sequence implicated in intercellular signaling. It mediates homophilic and heterophilic interactions that guide axon targeting and synapse specificity, particularly in the visual and hippocampal systems. Teneurin-3 interacts with latrophilins and other synaptic adhesion molecules to regulate synaptogenesis and neuronal circuit formation. Genetic disruption or altered expression of TENM3 has been linked to neurodevelopmental disorders, visual pathway defects, and certain cancers, highlighting its significance in neural development and disease.

Our chicken Anti-Teneurin-3 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N497/10. It detects human, mouse, and rat Teneurin-3, and is purified by affinity chromatography. It is great for use in ELISA, ICC, IHC, WB.

Recombinant protein comprising amino acids aa 161-201 and 343-396 (extracellular and cytoplasmic domains) of mouse Teneurin-3 (Tenm3, accession number Q9WTS6) connected by a Gly8 linker, produced recombinantly in E.Coli.

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N497/10 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N497/10 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and buffer exchanged into 1X PBS.

Each new lot of antibody is quality control tested by Western blot on rat brain membrane fraction and confirmed to stain the expected molecular weight band.