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L-selectin-Fc Chimera, Human, Purified Recombinant Protein

Selected Variant

PE-1247-10

Size: 10 µg

Product Specifications

Background

L-selection (CD26L) is a cell surface adhesion protein constitutively expressed on all classes of human leukocytes. The L-Selectin glycoprotein is composed of a C-type lectin family domain at the amino terminus, an EGF-like domain, two short consensus repeat (SCR) sequences, a transmembrane domain and a short cytoplasmic tail. L-Selectin contains 7 potential N- linked glycosylation sites.

Short Description

L-selectin-Fc Chimera, purified human recombinant protein, suitable to block.

Synonyms

Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62L; SELL; LNHR; LYAM1

UniProt

P14151

Target

L-selectin

Sequence

A DNA sequence encoding the signal peptide, pro-peptide and extracellular domain of human L-Selectin (amino acids 1-343) was fused to the Fc region of human IgG1 (amino acids 93-330) . The chimeric protein was expressed in modified human 293 cells.

Applications

Block

Format

Purified. The L-Selectin-Fc chimera consists of 20-45% carbohydrate by weight.

Buffer

When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.

Precautions

For research use only.

Shipping Conditions

25°C (ambient)

Storage Conditions

Reconstitute with sterile-filtered phosphate-buffered saline to a concentration of 100 μg/mL. Lyophilized products should be stored at 2 to 8°C. Following reconstitution, short-term storage at 2-8°C is recommended and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

Notes

>95% purity, as determined by SDS-PAGE and visualized by silver stain

Host or Source

HEK293

Physical Properties

Lyophilized

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