SCFR-Fc Chimera, Human, Purified Recombinant Protein
Product Specifications
Background
Stem Cell Factor Receptor (SCFR) is a member of the receptor tyrosine kinase family. Binding of SCFR to its ligand Stem Cell Factor (PE-2008-5) induces receptor dimerization, autophosphorylation and signal transduction. SCFR is essential for the development of normal hematopoietic cells and plays an important role in the survival, proliferation and differentiation of mast cells, melanocytes and germ cells.
Short Description
Stem cell factor receptor (SCFR) -Fc Chimera, purified human recombinant protein, suitable to block.
Synonyms
Mast/stem cell growth factor receptor; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117
UniProt
P10721
Target
Stem cell factor receptor (SCFR)
Sequence
A DNA sequence encoding the signal peptide and extracellular domain of human Stem Cell Factor Receptor (amino acids 1-520) was fused to the Fc region of human IgG1 (amino acids 93-330) . The chimeric protein was expressed in modified human 293 cells.
Applications
Block
Format
Purified. The SCFR-Fc Chimera consists of 5-45% carbohydrate by weight.
Buffer
When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Precautions
For research use only.
Shipping Conditions
25°C (ambient)
Storage Conditions
It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial. Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 2-8°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Notes
>95% purity, as determined by SDS-PAGE and visualized by silver stain
Host or Source
HEK293
Physical Properties
Lyophilized
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