EGFR-Fc Chimera, Human, Purified Recombinant Protein
Product Specifications
Background
Epidermal Growth Factor (EGF) Receptor binds to EGF and other members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. At least 4 isoforms are produced by alternative splicing (reference SWISSPROT) . The EGF receptor is a single-pass type I membrane protein containing an extracellular receptor domain, a transmembrane region and an intracellular domain with tyrosine kinase function.
Short Description
Epidermal growth factor receptor (EGFR) -Fc Chimera, purified human recombinant protein, suitable to block.
Synonyms
Receptor tyrosine-protein kinase erbB-1; EGFR; Urogastrone; Pro-epidermal growth factor; EGF R; c-erbB-1; ERBB1
UniProt
P00533
Target
Epidermal growth factor receptor (EGFR)
Sequence
A DNA sequence encoding the signal peptide and extracellular domain of human Epidermal Growth Factor Receptor (amino acids 1-525) was fused to the Fc region of human IgG1 (amino acids 90-330) . The chimeric protein was expressed in modified human 293 cells.
Applications
Block
Format
Purified. The EGF receptor-Fc chimera consists of 5-30% carbohydrate by weight.
Buffer
When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Precautions
For research use only.
Shipping Conditions
25°C (ambient)
Storage Conditions
It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial. Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 2-8°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Notes
>95% purity, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue
Host or Source
HEK293
Physical Properties
Lyophilized
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