TrkB-Fc Chimera, Human, Purified Recombinant Protein

TrkC is a member of the tropomyosin-related kinase receptor family. TrkC is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC is the receptor for neurotrophin-3 (NT-3) . Signalling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. TrkC is a heavily glycosylated molecule with 13 potential N-linked glycosylation sites within the extracellular domain.

Tropomyosin-related kinase receptor; NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC; TrkC-Fc Chimera

A DNA sequence encoding the signal peptide and extracellular domain of human TrkC (amino acids 1-428) was fused to the Fc region of human IgG1 (amino acids 93-330) . The chimeric protein was expressed in modified human 293 cells.

It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial. Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 2-8°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.