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Anti-Synuclein, pan Antibody

Our Anti-Pan-synuclein rabbit polyclonal primary antibody detects human, mouse, and rat Pan-synuclein , and is affinity-purified. It is validated for use in FC, WB.

Product Specifications

Background

A family of homologous proteins known as alpha-, beta-, and gamma-synuclein are abundantly expressed in brain, especially in the presynaptic terminal of neurons. Although the precise function of these proteins remains unknown, alpha-synuclein has been implicated in synaptic plasticity associated with avian song learning as well as in the pathogenesis of Parkinson's disease (PD), dementia with LBs (DLB), some forms of Alzheimer's disease (AD), and multiple system atrophy (MSA) .

Short Description

Our Anti-Pan-synuclein rabbit polyclonal primary antibody detects human, mouse, and rat Pan-synuclein, and is affinity-purified. It is validated for use in FC, WB.

UniProt

P37840; Q16143; O76070

Reactivity

Human, Mouse, and Rat

Immunogen

A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins has been used as the immunogen.

Target

Pan-synuclein

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

FC, WB

Format

Affinity-purified

Buffer

Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide

Precautions

For research use only.

Shipping Conditions

25°C (ambient)

Storage Conditions

Spin vial briefly before opening. Reconstitute in 100 μL of sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for long-term stability. Working aliquots can be kept at 2-8°C for up to 4 weeks, or longer with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.

Notes

Purified by affinity chromatography against the peptide immunogen.

WB Dilution

0.5-2 μg/mL

Specificity

Validated by Western blotting and flow cytometry. This antibody recognizes human, mouse, rat alpha-, beta- and gamma-synuclein.

Host or Source

Rabbit

Physical Properties

Lyophilized

Isotype

IgG

Immunogen Species

Human

Curated Selection

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