Anti-Beta-Synuclein Antibody

Our Anti-Beta-synuclein (β-synuclein, SNCB) mouse monoclonal primary antibody detects bovine, human, mouse, pig, and rat Beta-synuclein (β-synuclein, SNCB), and is affinity-purified. It is validated for use in IHC-Frozen, WB.

Product Specifications

Background

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA) -stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease (Ref: uniprot.org) .

Short Description

Synonyms

Beta-synuclein, β-synuclein

UniProt

Q16143

Reactivity

Bovine, Human, Mouse, Pig, and Rat

Immunogen

C-terminal peptide of human β-synuclein (EPEGESYEDPPQEEYQEYEPEA) coupled to KLH.

Target

Beta-synuclein (β-synuclein, SNCB)

Clonality

Monoclonal

Clone

6A10

Conjugation

Unconjugated

Applications

IHC-Frozen, WB

Format

Affinity-purified

Buffer

Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide

Precautions

For research use only.

Shipping Conditions

25°C (ambient)

Storage Conditions

Spin vial briefly before opening. Reconstitute with 100 μL sterile-filtered, ultrapure water to achieve a 1 mg/mL concentration. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C. After reconstitution divide into aliquots and store at -20°C for long-term storage. Store at 2-8°C short-term (up to 4 weeks) . Avoid repetitive freeze/thaw cycles.

Notes

Protein G purified

IHC Dilution

1:500-1:1000

WB Dilution

0.7361111111111112

Specificity

Validated by Western blotting and immunohistochemical procedures. Specific for β-synuclein, does not cross-react with α- or γ-synuclein.

Host or Source

Mouse

Physical Properties

Lyophilized

Isotype

IgG1

Immunogen Species

Human

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