Anti-Beta-synuclein Antibody

Our Anti-Beta-synuclein sheep polyclonal primary antibody detects human and rat Beta-synuclein , and is affinity-purified. It is validated for use in IHC-Frozen.

Product Specifications

Background

Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1) .

Short Description

Our Anti-Beta-synuclein sheep polyclonal primary antibody detects human and rat Beta-synuclein, and is affinity-purified. It is validated for use in IHC-Frozen.

Synonyms

SNCB

UniProt

Q16143

Reactivity

Human and Rat

Immunogen

A synthetic peptide (IEPLMEPEGSYEDPPQE) of human beta synuclein protein (aa: 108-125) conjugated to diptheria toxid has been used as the immunogen.

Target

Beta-synuclein

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC-Frozen

Format

Affinity-purified

Buffer

PBS with 0.02% sodium azide.

Precautions

For research use only.

Shipping Conditions

25°C (ambient)

Storage Conditions

Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.