Anti-Beta-synuclein Antibody
Our Anti-Beta-synuclein sheep polyclonal primary antibody detects human and rat Beta-synuclein , and is affinity-purified. It is validated for use in IHC-Frozen.
Product Specifications
Background
Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1) .
Short Description
Our Anti-Beta-synuclein sheep polyclonal primary antibody detects human and rat Beta-synuclein, and is affinity-purified. It is validated for use in IHC-Frozen.
Synonyms
SNCB
UniProt
Q16143
Reactivity
Human and Rat
Immunogen
A synthetic peptide (IEPLMEPEGSYEDPPQE) of human beta synuclein protein (aa: 108-125) conjugated to diptheria toxid has been used as the immunogen.
Target
Beta-synuclein
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC-Frozen
Format
Affinity-purified
Buffer
PBS with 0.02% sodium azide.
Precautions
For research use only.
Shipping Conditions
25°C (ambient)
Storage Conditions
Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
IHC Dilution
1 μg/mL
Specificity
Known to be specific for beta synuclein. This antiserum is known to react with beta synuclein of human, rat and other rodents.
Host or Source
Sheep
Physical Properties
Lyophilized
Isotype
IgG
Immunogen Species
Human
Frequently Asked Questions
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