Anti-Connexin-40 (Cx40) Antibody
Our Anti-Connexin-40 (Cx40) sheep polyclonal primary antibody detects rat Connexin-40 (Cx40), and is whole serum. It is validated for use in IHC, WB.
Product Specifications
Background
FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell. SUBUNIT: A connexon is composed of a hexamer of connexins. SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in lung. SIMILARITY: Belongs to the connexin family. Alpha-type (group II) subfamily.
Short Description
Our Anti-Connexin-40 (Cx40) sheep polyclonal primary antibody detects rat Connexin-40 (Cx40), and is whole serum. It is validated for use in WB.
Synonyms
Gap junction alpha-5 protein; Cx40; Gja5; Cxn-40
UniProt
P28234
Reactivity
Rat
Immunogen
A synthetic peptide consisting of amino acids 254 to 270 of the C-terminus of rat Cx40 (Cx40/254) conjugated to diphtheria toxoid has been used as the immunogen.
Target
Connexin-40 (Cx40)
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, WB
Format
Whole serum
Molecular Weight
40 kDa (See application details.)
Precautions
For research use only.
Shipping Conditions
25°C (ambient)
Storage Conditions
Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
IHC Dilution
1:100-1:250
WB Dilution
0.7361111111111112
Specificity
It is reported that the Cx40/254 antibody did not cross react with rat Cx43 but may with Cx45 in Western blots only (Rummery, NM et al 2002) .
Host or Source
Sheep
Physical Properties
Lyophilized
Isotype
IgG
Immunogen Species
Rat
Curated Selection
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