Anti-Nicastrin, Central region Antibody

Our Anti-Nicastrin, Central region rabbit polyclonal primary antibody detects human Nicastrin, Central region , and is igg. It is validated for use in WB, IP.

Product Specifications

Background

Nicastrin, a type 1 membrane glycoprotein, is an essential component of the gamma secretase complex which is critical for the cleavage of the amyloid precursor protein and other membrane proteins. Nicastrin is widely expressed in different tissue types. This antibody reacts with immature forms of Nicastrin. Detection of higher mol. wt. mature forms is likely to be blocked by glycosylation in this region of the protein.

Short Description

Our Anti-Nicastrin, Central region rabbit polyclonal primary antibody detects human Nicastrin, Central region, and is IgG. It is validated for use in ICC, WB.

UniProt

Q92542

Reactivity

Human

Immunogen

A synthetic peptide (C-QGETFDYIGSSRMVYD) corresponding to human Nicastrin [331-346] in the central region conjugated via additional N-terminal Cys to Diphtheria toxoid.

Target

Nicastrin, Central region

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB, IP

Format

IgG

Buffer

Lyophilized from PBS, pH 7.4. Contains no preservative.

Molecular Weight

145 kDa (See application details.)

Precautions

For research use only.

Shipping Conditions

25°C (ambient)

Storage Conditions

Spin vial briefly before opening. Reconstitute in 500 μL sterile-filtered 1X PBS, pH 7.2-7.6. Centrifuge to remove any insoluble material. Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.