Anti-Presenilin 1 loop region Antibody

Our Anti-Presenilin 1 loop region rabbit polyclonal primary antibody detects human and mouse Presenilin 1 loop region , and is igg. It is validated for use in WB.

Product Specifications

Background

Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot) .

Short Description

Our Anti-Presenilin 1 loop region rabbit polyclonal primary antibody detects human and mouse Presenilin 1 loop region, and is IgG. It is validated for use in WB.

Synonyms

Presenilin 1; PS-1; Protein S182; PS1-CTF12; PSEN1; AD3; PS1; PSNL1

UniProt

P49768

Reactivity

Human and Mouse

Immunogen

A synthetic peptide (GDPEAQRRVSKNSKYNA-C) corresponding to human PS1 [301-317] in the loop region conjugated via additional C-terminal Cys to Diphtheria toxoid.

Target

Presenilin 1 loop region

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Format

IgG

Buffer

Lyophilized from PBS, pH 7.4. Contains no preservative.

Molecular Weight

19 kDa, 45 kDa (See application details.)

Precautions

For research use only.

Shipping Conditions

25°C (ambient)

Storage Conditions

Spin vial briefly before opening. Reconstitute in 500 μL sterile-filtered 1X PBS, pH 7.2-7.6. Centrifuge to remove any insoluble material. Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.