Anti-MANF Antibody
Our Anti-Mesencephalic astrocyte-derived neurotrophic factor (MANF) rabbit polyclonal primary antibody detects human Mesencephalic astrocyte-derived neurotrophic factor (MANF), and is affinity-purified. It is validated for use in WB.
Product Specifications
Background
MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson's disease (Lindholm et al., 2008, Voutilainen et al., 2009) . When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
Short Description
Our Anti-Mesencephalic astrocyte-derived neurotrophic factor (MANF) rabbit polyclonal primary antibody detects human Mesencephalic astrocyte-derived neurotrophic factor (MANF), and is affinity-purified. It is validated for use in WB.
Synonyms
ARMET, ARP
UniProt
P55145
Reactivity
Human
Immunogen
Recombinant human MANF protein produced using CHO-based cell line. Immunogen is purified from cell culture supernatant.
Target
Mesencephalic astrocyte-derived neurotrophic factor (MANF)
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Format
Affinity-purified
Buffer
Concentrated ammonium sulphate in PBS pH 7.4 containing no preservatives.
Precautions
For research use only.
Shipping Conditions
2-8°C (on cold packs)
WB Dilution
1:2000-1:6000
Specificity
MANF (Mesencephalic astrocyte-derived neurotrophic factor) . No cross-reactivity in MANF-knockout mouse. No cross-reactivity with CDNF in IHC, slightly cross-reacts with purified CDNF in WB. No cross-reactivity with CDNF in IHC, slightly cross-reacts with purified CDNF in WB.
Host or Source
Rabbit
Physical Properties
Liquid
Isotype
IgG
Immunogen Species
Human
Frequently Asked Questions
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