Anti-MANF Antibody

Our Anti-Mesencephalic astrocyte-derived neurotrophic factor (MANF) rabbit polyclonal primary antibody detects human Mesencephalic astrocyte-derived neurotrophic factor (MANF), and is affinity-purified. It is validated for use in WB.

Product Specifications

Background

MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson's disease (Lindholm et al., 2008, Voutilainen et al., 2009) . When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.

Short Description

Synonyms

ARMET, ARP

UniProt

P55145

Reactivity

Human

Immunogen

Recombinant human MANF protein produced using CHO-based cell line. Immunogen is purified from cell culture supernatant.

Target

Mesencephalic astrocyte-derived neurotrophic factor (MANF)

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Format

Affinity-purified

Buffer

Concentrated ammonium sulphate in PBS pH 7.4 containing no preservatives.

Precautions

For research use only.

Shipping Conditions

2-8°C (on cold packs)

WB Dilution

1:2000-1:6000

Specificity

MANF (Mesencephalic astrocyte-derived neurotrophic factor) . No cross-reactivity in MANF-knockout mouse. No cross-reactivity with CDNF in IHC, slightly cross-reacts with purified CDNF in WB. No cross-reactivity with CDNF in IHC, slightly cross-reacts with purified CDNF in WB.