Anti-Noxa Antibody

Our Anti-Noxa rabbit polyclonal primary antibody detects mouse Noxa , and is whole serum. It is validated for use in WB.

Product Specifications

Background

The Bcl-2 family of proteins which regulate apoptosis share identical sequences called Bcl-2 Homology domains (BH1-4) . The BH3 proteins, including BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence identity within the amphipathic alpha-helical BH3 region, which is essential for their apoptotic function. NOXA is highly expressed in adult T-cell leukemia cell line.

Short Description

Our Anti-Noxa rabbit polyclonal primary antibody detects mouse Noxa, and is whole serum. It is validated for use in WB.

Synonyms

PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1; adult T cell leukemia-derived PMA-responsive; Immediate-early-response protein APR; PMA-induced protein 1; Pmaip1; Noxa

UniProt

Q9JM54

Reactivity

Mouse

Immunogen

A synthetic peptide (CAQLRR IGDKVNLRQK) as part of mouse Noxa (aa: 75-90) conjugated to diphtheria toxoid

Target

Noxa

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Format

Whole serum

Precautions

For research use only.

Shipping Conditions

25°C (ambient)

Storage Conditions

Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

WB Dilution

1:1000-1:2000

Specificity

Western blot analysis of cells infected with Noxa adenoviruses and BAF indicates a high level of specificity for this antiserum. This antiserum cross-reacts with mouse. Not yet tested in other species.