Anti-GFR alpha-2 Antibody

FUNCTION: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. SUBCELLULAR LOCATION: Cell membrane; lipid-anchor; GPI-anchor (By similarity) . ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing.

Our Anti-Glial cell-derived neurotrophic factor receptor alpha-2 (GFR alpha-2) rabbit polyclonal primary antibody detects human and rat Glial cell-derived neurotrophic factor receptor alpha-2 (GFR alpha-2), and is whole serum. It is validated for use in IHC-Frozen, WB.

GDNF family receptor alpha-2; GFR-alpha-2; Neurturin receptor alpha; NTNR-alpha; NRTNR-alpha; TGF-beta-related neurotrophic factor receptor 2; GDNF receptor beta; GDNFR-beta; RET ligand 2

Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Western blot analysis indicates a high level of specificity to GFR alpha-2 for this antiserum. This antibody is known to react with rat GFR alpha-2 and from IHC analysis, there appears to be no cross-reactivity with other members of the GFR family.