Anti-GDNF family receptor alpha-2 (GFR alpha-2) Antibody

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFR_-2 is a member of the GDNF receptor family. It is a glycosylphosphatidyl-inositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NRTN compared to its other family member, GDNF family receptor alpha 1.

Our Anti-GDNF family receptor alpha-2 (GFR alpha-2) chicken polyclonal primary antibody detects human GDNF family receptor alpha-2 (GFR alpha-2), and is affinity-purified. It is validated for use in ICC, WB.

GDNF receptor beta; Neurturin receptor alpha; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2; GDNFR-alpha-2; GFR-alpha-2; TRNR2; RETL2; GDNFRB

Recombinant His-tagged human GFR alpha-2 protein produced using CHO-based cell line. For production of hGFR alpha-2, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified by Ni-affinity chromatography following gel-filtration from cell culture supernatant.