Anti-GDNF family receptor alpha-1 (GFR alpha-1) Antibody
Our Anti-GDNF family receptor alpha-1 (GFR alpha-1) chicken polyclonal primary antibody detects human GDNF family receptor alpha-1 (GFR alpha-1), and is affinity-purified. It is validated for use in ICC, WB.
Product Specifications
Background
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The GFR_-1 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor (www.ncbi.nlm.nih.gov/gene/2674) .
Short Description
Our Anti-GDNF family receptor alpha-1 (GFR alpha-1) chicken polyclonal primary antibody detects human GDNF family receptor alpha-1 (GFR alpha-1), and is affinity-purified. It is validated for use in ICC, WB.
Synonyms
RET ligand 1; TGF-beta related neurotrophic factor receptor 1; GDNFR-alpha-1; GFR-alpha-1; TRNR1; RETL1; GFRA1
UniProt
P56159
Reactivity
Human
Immunogen
Recombinant His-tagged human GFR alpha-1 protein produced using CHO-based cell line. For production of hGFR alpha-1, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified by Ni-affinity chromatography following gel-filtration from cell culture supernatant.
Target
GDNF family receptor alpha-1 (GFR alpha-1)
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
ICC, WB
Format
Affinity-purified
Buffer
Concentrated ammonium sulphate in PBS pH 7.4 containing no preservatives.
Precautions
For research use only.
Shipping Conditions
2-8°C (on cold packs)
WB Dilution
1:5000-1:10000
Specificity
Human GFR alpha-1. No cross reaction with hGFR alpha-2, hGFR alpha-3, hGFR alpha-4.
ICC Dilution
1:500-1:2000
Host or Source
Chicken
Physical Properties
Liquid
Isotype
IgY
Immunogen Species
Human
Frequently Asked Questions
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