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Abatacept Biosimilar - Research Grade

Product Specifications

Background

Recombinant protein composed of the extracellular domain of CTLA-4 fused with the Fc region of human immunoglobulin gamma 1 (hIgG1) . Abatacept binds to CD80 (B7-1) with more avidity than to CD86 (B7-2) .

Host

CHO Cells

Reactivity

Human

Target

CTLA-4 Fc Fusion Protein

Sequence

https://www.imgt.org/mAb-DB/

Applications

Functional Assays

Purification Method

This fusion protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

5mg/mL

Endotoxin

<1EU/mg Determined by LAL gel clotting assay

Purity

≥95% monomer by analytical SEC, >95% by SDS Page

Buffer

ICH3002

Shipping Conditions

Blue ice

Storage Conditions

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Specificity

Fusion protein of a Fc fragment (human IgG1 isotype) and the extracellular domain of CTLA-4

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Applications Notes

This biosimilar is for research use only (RUO) : it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

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