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Blinatumomab Biosimilar - Research Grade

Product Specifications

Background

Blinatumomab is a bispecific T-cell engager (BiTE) . It enables a patient’s T cells to recognize malignant B cells. A molecule of blinatumomab combines two binding sites: a CD3 site for T cells and a CD19 site for the target B cells.

Reactivity

Human

Target

CD3 + CD19

Sequence

https://www.imgt.org/mAb-DB/

Applications

Functional Assays

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

5mg/mL

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>90% by SDS-PAGE

Buffer

ICH3002

References & Citations

Mancusi et al. Blinatumomab Redirects Donor Lymphocytes against CD19+ Acute Lymphoblastic Leukemia without Relevant Bystander Alloreactivity after Haploidentical Hematopoietic Stem Cell Transplantation. Int. J. Mol. Sci. 2023, 24 (22), 16105

Shipping Conditions

Blue ice

Storage Conditions

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Fragment

ScFv-His

Specificity

Detects human CD3/CD19. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Blinatumomab.

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Applications Notes

This biosimilar is for research use only (RUO) : it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

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