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Monalizumab Biosimilar - Ultra Low Endotoxin

Product Specifications

Background

RUO monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response.

Product Name Alternative

KLRC1, NKG2A, CD159a, CD94

UniProt

P26715

Reactivity

Human

Target

NKG2A

Isotype

IgG4

Sequence

https://www.imgt.org/mAb-DB/

Applications

Functional Assays

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

5mg/mL

Endotoxin

≤ 0.1 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE

Buffer

ICH3002

Shipping Conditions

Blue ice

Storage Conditions

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Specificity

Detects human CD159a. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Monalizumab.

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Applications Notes

This biosimilar is for research use only (RUO) : it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Isotype Control

Bulk Human IgG4 Isotype Control (IB4) [ICH2257]

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