Girentuximab Biosimilar - Research Grade

Product Specifications

Background

RUO girentuximab binds to the extracellular proteoglycan (PG) -like domain, which is unique to CA IX compared to other isoforms and lies adjacent to the catalytic domain. In addition to therapy, girentuximab has also been utilized as an imaging agent.

Product Name Alternative

CAIX, CA-IX

UniProt

Q16790

Reactivity

Human

Target

Carbonic Anhydrase IX

Isotype

IgG1

Sequence

https://www.imgt.org/mAb-DB/

Applications

Functional Assays

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

5mg/mL

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE

Buffer

ICH3002

Shipping Conditions

Blue ice

Storage Conditions

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Specificity

Detects human Carbonic Anhydrase IX. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Girentuximab Biosimilar - Research Grade.