Vedolizumab Biosimilar - Ultra Low Endotoxin
Product Specifications
Background
Vedolizumab, an integrin receptor antagonist, is a humanized IgG1 monoclonal antibody produced in Chinese hamster ovary cells that binds to the human α4β7 integrin. Vedolizumab has an approximate molecular weight of 147 kilodaltons.
Product Name Alternative
ITGA4, ITGB7
UniProt
P13612
Host
Humanized
Reactivity
Human
Target
Integrin alpha 4 + beta 7
Isotype
IgG1
Sequence
https://www.imgt.org/mAb-DB/
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
1.0 - 5.0 mg/mL
Endotoxin
≤ 0.1 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE and HPLC
Buffer
ICH3001-100ml ICH3002-100ml ICH3003-100ml
Shipping Conditions
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Specificity
Detects human Integrin alpha 4 + beta 7. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Vedolizumab.
Formulation
Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Isotype Control
Bulk Human IgG1 Isotype Control (IB1) [ICH2254]
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