Pembrolizumab Biosimilar - Research Grade
Product Specifications
Background
Pembrolizumab biosimilar is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. It is an IgG4 kappa immunoglobulin with an approximate molecular weight of 149 kDa.
Product Name Alternative
Programmed cell death protein 1, Pdcd1, CD279
UniProt
Q15116
Host
Humanized
Reactivity
Human
Target
PD-1
Isotype
IgG4 κ
Sequence
https://www.imgt.org/mAb-DB/
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
1.0 - 5.0 mg/mL
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE and HPLC
Buffer
ICH3001-100ml ICH3002-100ml ICH3003-100ml
Shipping Conditions
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Specificity
Detects human PD-1. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Pembrolizumab.
Formulation
Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Isotype Control
Bulk Human IgG4 Isotype Control (IB4) [ICH2257]
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