Nimotuzumab Biosimilar - Research Grade

Product Specifications

Background

Nimotuzumab biosimilar has a humanized human-mouse h-R3 heavy chain and a humanized human-mouse h-R3κ-chain. nimotuzumab binds to the epidermal growth factor receptor (EGFR), a signalling protein that normally controls cell division.

Product Name Alternative

Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, ERBB, ERBB1, HER1

UniProt

P00533

Host

Humanized

Reactivity

Human

Target

EGFR

Isotype

IgG1 κ

Sequence

https://www.imgt.org/mAb-DB/

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

1.0 - 5.0 mg/mL

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE and HPLC

Buffer

ICH3001-100ml ICH3002-100ml ICH3003-100ml

References & Citations

Simultaneous Imaging and Therapy Using Epitope-Specific Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Conjugates

Shipping Conditions

Blue ice

Storage Conditions

Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.