Anti-Rat CD71 (OX-26) In Vivo Antibody - Low Endotoxin
Product Specifications
Background
CD71 is a transferrin receptor on the cell surface that mediates the uptake of transferrin-iron complexes, thereby mediating cellular proliferation. CD71 is a homodimeric glycoprotein containing 760 amino acids and it binds to diferric transferrin. Binding by diferric transfferin causes CD71 to be internalized, and diferric iron is subsequently released. CD71 is highly expressed on malignant cells, as iron uptake is necessary for aberrant cell proliferation.
Host
Mouse
Reactivity
Mouse, Rat
Target
CD71
Isotype
IgG2a
Clone
OX-26
Applications
Flow Cytometry, Immunohistochemistry
Purification Method
This monoclonal antibody was purified using Protein A
Concentration
≥ 2.0 mg/mL
Endotoxin
<1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE
Buffer
ICH3001-100ml ICH3002-100ml ICH3003-100ml
Shipping Conditions
Blue ice
Storage Conditions
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Specificity
Clone OX-26 reacts with mouse and rat CD71 (TfR1) .
Formulation
Sterile, preservative-free, solution in PBS. BSA and Azide free.
Antigen Distribution
CD71 is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors.
Aggregation
Aggregation level ≤ 5%
Applications Notes
Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control
Mouse IgG2a In Vivo Isotype Control – Low Endotoxin (C1.18.4) [ICH2245]
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