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Anti-Mouse CD70 (TAN 1-7) In Vivo Antibody - Low Endotoxin

Selected Variant

ICH1169-1mg

Size: 1 mg

Product Specifications

Background

CD70, a cytokine and also known as CD27 ligand, is a member of the tumor necrosis family. As a cytokine, CD70 plays a role in regulating B cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. Non-small cell lung cancer research has shown that CD70 increases the survivability of tumor cells and T cells by signaling through its receptor CD27.

Product Name Alternative

CD27 Ligand, TNFSF7, Tumor Necrosis Factor Ligand 8A, CD27L, CD70 Antigen

UniProt

O55237

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant mouse CD70 (extracellular domain, aa residues 41-195) .

Target

CD70

Isotype

IgG2a κ

Clone

TAN1-7

Applications

ELISA, Flow Cytometry, Immunofluorescence, Blocking

Purification Method

This monoclonal antibody was purified using Protein G

Concentration

>2.0 mg/mL

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE and HPLC

Buffer

ICH3001-100ml ICH3002-100ml ICH3003-100ml

Shipping Conditions

Blue ice

Storage Conditions

This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Specificity

Clone TAN 1-7 recognizes mouse CD70.

Formulation

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 – 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and azide free

Antigen Distribution

CD70 is expressed on activated T Cells, B Cells, and dendritic cells.

Aggregation

Aggregation level ≤ 5%

Applications Notes

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control

Rat IgG2a In Vivo Isotype Control – Low Endotoxin (1-1)

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