Anti-Mouse CD70 (TAN 1-7) In Vivo Antibody - Low Endotoxin
Product Specifications
Background
CD70, a cytokine and also known as CD27 ligand, is a member of the tumor necrosis family. As a cytokine, CD70 plays a role in regulating B cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. Non-small cell lung cancer research has shown that CD70 increases the survivability of tumor cells and T cells by signaling through its receptor CD27.
Product Name Alternative
CD27 Ligand, TNFSF7, Tumor Necrosis Factor Ligand 8A, CD27L, CD70 Antigen
UniProt
O55237
Host
Rat
Reactivity
Mouse
Immunogen
Recombinant mouse CD70 (extracellular domain, aa residues 41-195) .
Target
CD70
Isotype
IgG2a κ
Clone
TAN1-7
Applications
ELISA, Flow Cytometry, Immunofluorescence, Blocking
Purification Method
This monoclonal antibody was purified using Protein G
Concentration
>2.0 mg/mL
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE and HPLC
Buffer
ICH3001-100ml ICH3002-100ml ICH3003-100ml
Shipping Conditions
Blue ice
Storage Conditions
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Specificity
Clone TAN 1-7 recognizes mouse CD70.
Formulation
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 – 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and azide free
Antigen Distribution
CD70 is expressed on activated T Cells, B Cells, and dendritic cells.
Aggregation
Aggregation level ≤ 5%
Applications Notes
Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control
Rat IgG2a In Vivo Isotype Control – Low Endotoxin (1-1)
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