Anti-Phospho-ATF4 (S219) Antibody
Boster Bio Anti-Phospho-ATF4 (S219) Antibody catalog # P00371. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
ATF4, Activating Transcription Factor 4, is also known as CREB2. ATF4 belongs to the large ATF/CREB family of transcription factors which bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. It is identified that members of this family share significant sequence similarity within a leucine zipper DNA-binding motif and an adjacent basic region. The ATF4 gene is mapped to chromosome 22. Unlike CREB, which activates transcription from CRE-containing promoters, CREB2 functions as a specific repressor of CRE-dependent transcription. The transcriptional repressor activity resides within the C-terminal leucine zipper and basic domain region of the CREB2 protein.
Synonyms
ATF4; CREB 2; CREB2; DNA binding protein TAXREB67; TAXREB67; TXREB
Gene Name
ATF4
UniProt
P18848
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthesized peptide derived from human ATF4 around the phosphorylation site of Ser219.
Clonality
Polyclonal
Applications
WB
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Applications Notes
Western blot, 1:500-2000
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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