Anti-Phospho-FOXM1 (S35) Antibody

Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.

FKHL16; forkhead box M1; FOXM1; FOXM1B; HFH 11; HFH11; HNF 3; HNF 3/fork head homolog 11; INS 1; M phase phosphoprotein 2; MPHOSPH2; MPP 2; MPP2; PIG29; TGT3; Transcription factor Trident; TRIDENT; WIN